DocHero AI - Best paraphrasing and translation tool for academic and professional writing | DocHero AI - Best paraphrasing and translation tool for academic and professional writing

Discovery of a highly selective JAK3 inhibitor for the treatment of rheumatoid arthritis

Heying Pei, Linhong He, Mingfeng Shao et al. (14 total)

2018-3-27

Scientific Reports Vol. 8 (1)

10.1038/s41598-018-23569-y

摘要

AbstractJanus tyrosine kinase 3 (JAK3) is expressed in lymphoid cells and is involved in the signalling of T cell functions. The development of a selective JAK3 inhibitor has been shown to have a potential benefit in the treatment of autoimmune disorders. In this article, we developed the 4-aminopiperidine-based compound RB1, which was highly selective for JAK3 inhibition, with an IC50 of value of 40 nM, but did not inhibit JAK1, JAK2 or tyrosine kinase 2 (TYK2) at concentrations up to 5 µM. Fur...

查看文献